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The authors also observed a marked decrease in vascular BH 4 content and identified the endothelium as the pivotal superoxide source compatible with eNOS uncoupling

Immunogenicity: Some carrier polymers, e.g., poly-lactic acid and poly-lactic-co-glycolic acid, may activate unexpected immunological responses and generate inflammatory byproducts, which can impair therapeutic efficacy and health safety (Wu et al., 2022)

Statements Author contributions BC obtained funding, conceived and designed experiments, analyzed data, proposed model, and wrote the manuscript

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